Characteristics of the gut microbiome profile in obese patients with colorectal cancer.

ABSTRACT:

Background and aim

Obesity affects the gut microbiome, which in turn increases the risk for colorectal cancer. Several studies have shown the mechanisms by which some bacteria may influence the development of colorectal cancer; however, gut microbiome characteristics in obese patients with colorectal cancer remain unclear. Therefore, this study evaluated their gut microbiome profile and its relationship with metabolic markers.

Methods

The study assessed fecal samples from 36 consecutive patients with colorectal cancer and 38 controls without colorectal cancer. To identify microbiotic variations between patients with colorectal cancer and controls, as well as between nonobese and obese individuals, 16S rRNA gene amplicon sequencing was performed.

Results

Principal coor

SUBMITTER: Shoji M 

PROVIDER: S-EPMC8035457 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature