Controlled human exposures to diesel exhaust: a human epigenome-wide experiment of target bronchial epithelial cells.

ABSTRACT: Diesel exhaust (DE) is a major contributor to ambient air pollution around the world. It is a known human carcinogen that targets the respiratory system and increases risk for many diseases, but there is limited research on the effects of DE exposure on the epigenome of human bronchial epithelial cells. Understanding the epigenetic impact of this environmental pollutant can elucidate biological mechanisms involved in the pathogenesis of harmful DE-related health effects. To estimate the causal effect of short-term DE exposure on the bronchial epithelial epigenome, we conducted a controlled single-blinded randomized crossover human experiment of exposure to DE and used bronchoscopy and Illumina 450K arrays for data collection and analysis, respectively. Of the 13 participants, 11 (85%) were

SUBMITTER: Cardenas A 

PROVIDER: S-EPMC8035831 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature