Comparative use of aqueous humour ¹H NMR metabolomics and potassium concentration for PMI estimation in an animal model.

ABSTRACT: Estimation of the post-mortem interval (PMI) remains a matter of concern in the forensic scenario. Traditional and novel approaches are not yet able to fully address this issue, which relies on complex biological phenomena triggered by death. For this purpose, eye compartments may be chosen for experimental studies because they are more resistant to post-mortem modifications. Vitreous humour, in particular, has been extensively investigated, with potassium concentration ([K⁺]) being the marker that is better correlated with PMI estimation. Recently, a ¹H nuclear magnetic resonance (NMR) metabolomic approach based on aqueous humour (AH) from an animal model was proposed for PMI estimation, resulting in a robust and validated regression model. Here we studied the variat

SUBMITTER: Locci E 

PROVIDER: S-EPMC8036180 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature