Sentinel lymph node detection in oral cancer: a within-patient comparison between [^99mTc]Tc-tilmanocept and [^99mTc]Tc-nanocolloid.

ABSTRACT:

Purpose

Sentinel lymph node (SLN) biopsy has proven to reliably stage the clinically negative neck in early-stage oral squamous cell carcinoma (OSCC). [^99mTc]Tc-tilmanocept may be of benefit in OSCC with complex lymphatic drainage patterns and close spatial relation to SLNs.

Methods

A prospective within-patient evaluation study was designed to compare [^99mTc]Tc-tilmanocept with [^99mTc]Tc-nanocolloid for SLN detection. A total of 20 patients with early-stage OSCC were included, who underwent lymphoscintigraphy with both tracers. Both lymphoscintigraphic images of each patient were evaluated for SLN detection and radiotracer distribution at 2-4 h post-injection.

Results

The injection site's remaining radioactivity was significantly lower

SUBMITTER: den Toom IJ 

PROVIDER: S-EPMC8036184 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature