(+)-[¹⁸F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand-results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer's disease and healthy controls.

ABSTRACT:

Purposes

We present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)-targeting radioligand (+)-[¹⁸F]Flubatine. Aims were to develop a kinetic modeling-based approach to quantify (+)-[¹⁸F]Flubatine and compare the data of healthy controls (HCs) and patients with Alzheimer's disease (AD); to investigate the partial volume effect (PVE) on regional (+)-[¹⁸F]Flubatine binding; and whether (+)-[¹⁸F]Flubatine binding and cognitive test data respective β-amyloid radiotracer accumulation were correlated.

Methods

We examined 11 HCs and 9 mild AD patients. All subjects underwent neuropsychological testing and [¹¹C]PiB PET/MRI examination. (+)-[¹⁸F]Flubatine PET data were

SUBMITTER: Tiepolt S 

PROVIDER: S-EPMC8036219 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature