Exogenous Integrin αIIbβ3 Inhibitors Revisited: Past, Present and Future Applications.

ABSTRACT: The integrin αIIbβ3 is the most abundant integrin on platelets. Upon platelet activation, the integrin changes its conformation (inside-out signalling) and outside-in signalling takes place leading to platelet spreading, platelet aggregation and thrombus formation. Bloodsucking parasites such as mosquitoes, leeches and ticks express anticoagulant and antiplatelet proteins, which represent major sources of lead compounds for the development of useful therapeutic agents for the treatment of haemostatic disorders or cardiovascular diseases. In addition to hematophagous parasites, snakes also possess anticoagulant and antiplatelet proteins in their salivary glands. Two snake venom proteins have been developed into two antiplatelet drugs that are currently used in the clinic. The group of prote

SUBMITTER: van den Kerkhof DL 

PROVIDER: S-EPMC8036306 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature