Alkaloids Used as Medicines: Structural Phytochemistry Meets Biodiversity-An Update and Forward Look.

ABSTRACT: Selecting candidates for drug developments using computational design and empirical rules has resulted in a broad discussion about their success. In a previous study, we had shown that a species' abundance [as expressed by the GBIF (Global Biodiversity Information Facility)] dataset is a core determinant for the development of a natural product into a medicine. Our overarching aim is to understand the unique requirements for natural product-based drug development. Web of Science was queried for research on alkaloids in combination with plant systematics/taxonomy. All alkaloids containing species demonstrated an average increase of 8.66 in GBIF occurrences between 2014 and 2020. Medicinal Species with alkaloids show higher abundance compared to non-medicinal alkaloids, often linked also to

SUBMITTER: Heinrich M 

PROVIDER: S-EPMC8036335 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature