Model of Environmental Membrane Field for Transmembrane Proteins.

ABSTRACT: The water environment determines the activity of biological processes. The role of such an environment interpreted in the form of an external field expressed by the 3D Gaussian distribution in the fuzzy oil drop model directs the folding process towards the generation of a centrally located hydrophobic core with the simultaneous exposure of polar residues on the surface. In addition to proteins soluble in the water environment, there is a significant group of membrane proteins that act as receptors or channels, including ion channels in particular. The change of the polar (water) environment into a highly hydrophobic (membrane) environment is quite radical, resulting in a different hydrophobicity distribution within the membrane protein. Modification of the notation of the force field expr

SUBMITTER: Roterman I 

PROVIDER: S-EPMC8036355 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature