Vitamin D Deficiency Induces Chronic Pain and Microglial Phenotypic Changes in Mice.

ABSTRACT: The bioactive form of vitamin D, 1,25-dihydroxyvitamin D (1,25D3), exerts immunomodulatory actions resulting in neuroprotective effects potentially useful against neurodegenerative and autoimmune diseases. In fact, vitamin D deficiency status has been correlated with painful manifestations associated with different pathological conditions. In this study, we have investigated the effects of vitamin D deficiency on microglia cells, as they represent the main immune cells responsible for early defense at central nervous system (CNS), including chronic pain states. For this purpose, we have employed a model of low vitamin D intake during gestation to evaluate possible changes in primary microglia cells obtained from postnatal day(P)2-3 pups. Afterwards, pain measurement and microglia morpholog

SUBMITTER: Alessio N 

PROVIDER: S-EPMC8036382 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature