Understanding the Molecular Basis of 5-HT₄ Receptor Partial Agonists through 3D-QSAR Studies.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder whose prevalence has an incidence in senior citizens. Unfortunately, current pharmacotherapy only offers symptom relief for patients with side effects such as bradycardia, nausea, and vomiting. Therefore, there is a present need to provide other therapeutic alternatives for treatments for these disorders. The 5-HT₄ receptor is an attractive therapeutic target since it has a potential role in central and peripheral nervous system disorders such as AD, irritable bowel syndrome, and gastroparesis. Quantitative structure-activity relationship analysis of a series of 62 active compounds in the 5-HT₄ receptor was carried out in the present work. The structure-activity relationship was estimated using three-dimensional

SUBMITTER: Castro-Alvarez A 

PROVIDER: S-EPMC8036435 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature