Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase α1^s/sα2^s/s Mouse Model of High Affinity for Cardiotonic Steroids.

ABSTRACT: The Na/K-ATPase is the specific receptor for cardiotonic steroids (CTS) such as ouabain and digoxin. At pharmacological concentrations used in the treatment of cardiac conditions, CTS inhibit the ion-pumping function of Na/K-ATPase. At much lower concentrations, in the range of those reported for endogenous CTS in the blood, they stimulate hypertrophic growth of cultured cardiac myocytes through initiation of a Na/K-ATPase-mediated and reactive oxygen species (ROS)-dependent signaling. To examine a possible effect of endogenous concentrations of CTS on cardiac structure and function in vivo, we compared mice expressing the naturally resistant Na/K-ATPase α1 and age-matched mice genetically engineered to express a mutated Na/K-ATPase α1 with high affinity for CTS. In this model, total cardi

SUBMITTER: Marck PV 

PROVIDER: S-EPMC8036649 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature