Evodiamine Inhibits Helicobacter pylori Growth and Helicobacter pylori-Induced Inflammation.

ABSTRACT: Helicobacter pylori (H. pylori) classified as a class I carcinogen by the World Health Organization (WHO) plays an important role in the progression of chronic gastritis and the development of gastric cancer. A major bioactive component of Evodia rutaecarpa, evodiamine, has been known for its anti-bacterial effect and anti-cancer effects. However, the inhibitory effect of evodiamine against H. pylori is not yet known and the inhibitory mechanisms of evodiamine against gastric cancer cells are yet to be elucidated concretely. In this study, therefore, anti-bacterial effect of evodiamine on H. pylori growth and its inhibitory mechanisms as well as anti-inflammatory effects and its mechanisms of evodiamine on H. pylori-induced inflammation were invest

SUBMITTER: Yang JY 

PROVIDER: S-EPMC8036659 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature