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Merkel Cell Carcinoma: New Trends.

ABSTRACT: Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin mainly seen in the elderly. Its incidence is rising due to ageing of the population, increased sun exposure, and the use of immunosuppressive medication. Additionally, with the availability of specific immunohistochemical markers, MCC is easier to recognize. Typically, these tumors are rapidly progressive and behave aggressively, emphasizing the need for early detection and prompt diagnostic work-up and start of treatment. In this review, the tumor biology and immunology, current diagnostic and treatment modalities, as well as new and combined therapies for MCC, are discussed. MCC is a very immunogenic tumor which offers good prospects for immunotherapy. Given its rarity, the aggressiveness, and the frail patient population it concerns, MCC should be managed in close collaboration with an experienced multidisciplinary team.

SUBMITTER: Zwijnenburg EM

PROVIDER: S-EPMC8036880 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Merkel Cell Carcinoma: New Trends.

Zwijnenburg Ellen M EM Lubeek Satish F K SFK Werner Johanna E M JEM Amir Avital L AL Weijs Willem L J WLJ Takes Robert P RP Pegge Sjoert A H SAH van Herpen Carla M L CML Adema Gosse J GJ Kaanders Johannes H A M JHAM

Cancers 20210331 7

Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin mainly seen in the elderly. Its incidence is rising due to ageing of the population, increased sun exposure, and the use of immunosuppressive medication. Additionally, with the availability of specific immunohistochemical markers, MCC is easier to recognize. Typically, these tumors are rapidly progressive and behave aggressively, emphasizing the need for early detection and prompt diagnostic work-up and start of treatment. In ...[more]

PMID: 33807446

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