Myc-Related Mitochondrial Activity as a Novel Target for Multiple Myeloma.

ABSTRACT: Mitochondria are involved in the development and acquisition of a malignant phenotype in hematological cancers. Recently, their role in the pathogenesis of multiple myeloma (MM) has been suggested to be therapeutically explored. MYC is a master regulator of b-cell malignancies such as multiple myeloma, and its activation is known to deregulate mitochondrial function. We investigated the impact of mitochondrial activity on the distinct entities of the disease and tested the efficacy of the mitochondrial inhibitor, tigecycline, to overcome MM proliferation. COXII expression, COX activity, mitochondrial mass, and mitochondrial membrane potential demonstrated a progressive increase of mitochondrial features as the disease progresses. In vitro and in vivo therapeutic targeting using the mitocho

SUBMITTER: Ortiz-Ruiz A 

PROVIDER: S-EPMC8037116 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature