Malignant Pleural Mesothelioma Interactome with 364 Novel Protein-Protein Interactions.

ABSTRACT: Malignant pleural mesothelioma (MPM) is an aggressive cancer affecting the outer lining of the lung, with a median survival of less than one year. We constructed an 'MPM interactome' with over 300 computationally predicted protein-protein interactions (PPIs) and over 2400 known PPIs of 62 literature-curated genes whose activity affects MPM. Known PPIs of the 62 MPM associated genes were derived from Biological General Repository for Interaction Datasets (BioGRID) and Human Protein Reference Database (HPRD). Novel PPIs were predicted by applying the HiPPIP algorithm, which computes features of protein pairs such as cellular localization, molecular function, biological process membership, genomic location of the gene, and gene expression in microarray experiments, and classifies the pairwise

SUBMITTER: Karunakaran KB 

PROVIDER: S-EPMC8037232 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature