The Role of [¹⁸F]Fluciclovine PET/CT in the Characterization of High-Risk Primary Prostate Cancer: Comparison with [¹¹C]Choline PET/CT and Histopathological Analysis.

ABSTRACT: The primary aim of the study was to evaluate the role of [¹⁸F]Fluciclovine PET/CT in the characterization of intra-prostatic lesions in high-risk primary PCa patients eligible for radical prostatectomy, in comparison with conventional [¹¹C]Choline PET/CT and validated by prostatectomy pathologic examination. Secondary aims were to determine the performance of PET semi-quantitative parameters (SUVmax; target-to-background ratios [TBRs], using abdominal aorta, bone marrow and liver as backgrounds) for malignant lesion detection (and best cut-off values) and to search predictive factors of malignancy. A six sextants prostate template was created and used by PET readers and pathologists for data comparison and validation. PET visual and semi-quantitative analyses were per

SUBMITTER: Zanoni L 

PROVIDER: S-EPMC8037300 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature