Transcript Regulation of the Recoded Archaeal α-l-Fucosidase In Vivo.

ABSTRACT: Genetic decoding is flexible, due to programmed deviation of the ribosomes from standard translational rules, globally termed "recoding". In Archaea, recoding has been unequivocally determined only for termination codon readthrough events that regulate the incorporation of the unusual amino acids selenocysteine and pyrrolysine, and for -1 programmed frameshifting that allow the expression of a fully functional α-l-fucosidase in the crenarchaeon Saccharolobus solfataricus, in which several functional interrupted genes have been identified. Increasing evidence suggests that the flexibility of the genetic code decoding could provide an evolutionary advantage in extreme conditions, therefore, the identification and study of interrupted genes in extremophilic Archaea could be important from an

SUBMITTER: De Lise F 

PROVIDER: S-EPMC8037382 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature