Stiffness and Aging in Cardiovascular Diseases: The Dangerous Relationship between Force and Senescence.
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SUBMITTER: Ferrari S
PROVIDER: S-EPMC8037660 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
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Stiffness and Aging in Cardiovascular Diseases: The Dangerous Relationship between Force and Senescence.
Ferrari Silvia S Pesce Maurizio M
International journal of molecular sciences 20210326 7
Biological aging is a process associated with a gradual decline in tissues' homeostasis based on the progressive inability of the cells to self-renew. Cellular senescence is one of the hallmarks of the aging process, characterized by an irreversible cell cycle arrest due to reactive oxygen species (ROS) production, telomeres shortening, chronic inflammatory activation, and chromatin modifications. In this review, we will describe the effects of senescence on tissue structure, extracellular matri ...[more]
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