Counteracting the Ramifications of UVB Irradiation and Photoaging with Swietenia macrophylla King Seed.

ABSTRACT: In this day and age, the expectation of cosmetic products to effectively slow down skin photoaging is constantly increasing. However, the detrimental effects of UVB on the skin are not easy to tackle as UVB dysregulates a wide range of molecular changes on the cellular level. In our research, irradiated keratinocyte cells not only experienced a compromise in their redox system, but processes from RNA translation to protein synthesis and folding were also affected. Aside from this, proteins involved in various other processes like DNA repair and maintenance, glycolysis, cell growth, proliferation, and migration were affected while the cells approached imminent cell death. Additionally, the collagen degradation pathway was also activated by UVB irradiation through the upregulation of inflamm

SUBMITTER: Mahendra CK 

PROVIDER: S-EPMC8037697 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature