Rapid Prototyping of a Nanoparticle Concentrator Using a Hydrogel Molding Method.

ABSTRACT: Nanoparticle (NP) concentration is crucial for liquid biopsies and analysis, and various NP concentrators (NPCs) have been developed. Methods using ion concentration polarization (ICP), an electrochemical phenomenon based on NPCs consisting of microchannels, have attracted attention because samples can be non-invasively concentrated using devices with simple structures. The fabrication of such NPCs is limited by the need for lithography, requiring special equipment and time. To overcome this, we reported a rapid prototyping method for NPCs by extending the previously developed hydrogel molding method, a microchannel fabrication method using hydrogel as a mold. With this, we fabricated NPCs with both straight and branched channels, typical NPC configurations. The generation of ICP was verif

SUBMITTER: Hirama H 

PROVIDER: S-EPMC8037731 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature