Synthesis and Characterization of a Minophosphonate Containing Chitosan Polymer Derivatives: Investigations of Cytotoxic Activity and in Silico Study of SARS-CoV-19.

ABSTRACT: Chitosan is broadly used as a biological material since of its excellent biological activities. This work describes investigations of chitosan interaction with SARS-CoV-2, which is occupied by human respiratory epithelial cells through communication with the human angiotension-converting enzyme II (ACE2). The β-chitosan derivatives are synthesized and characterized by FT-IR, nuclear magnetic resonance (¹H and ¹³C NMR), mass spectrometry, X-ray diffraction, TGA, DSC, and elemental analysis. The β-chitosan derivatives were screened for cytotoxic activity against the HepG2 and MCF-7 (breast) cancer cell lines. Compound 1h (GI₅₀ 0.02 µM) is moderately active against the HepG2 cancer cell line, and Compound 1c is highly active (GI₅₀ 0.01

SUBMITTER: Packialakshmi P 

PROVIDER: S-EPMC8038110 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature