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Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410^6.30×30K Variant in the Histamine H₁ Receptor.

ABSTRACT: The Exome Aggregation Consortium has collected the protein-encoding DNA sequences of almost 61,000 unrelated humans. Analysis of this dataset for G protein-coupled receptor (GPCR) proteins (available at GPCRdb) revealed a total of 463 naturally occurring genetic missense variations in the histamine receptor family. In this research, we have analyzed the distribution of these missense variations in the four histamine receptor subtypes concerning structural segments and sites important for GPCR function. Four missense variants R127^3.52×52H, R139^34.57×57H, R409^6.29×29H, and E410^6.30×30K, were selected for the histamine H₁ receptor (H₁R) that were hypothesized to affect receptor activity by interfering with the interaction patte

SUBMITTER: Ma X

PROVIDER: S-EPMC8038156 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410^6.30×30K Variant in the Histamine H₁ Receptor.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E4106.30×30K Variant in the Histamine H1 Receptor.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410^6.30×30K Variant in the Histamine H₁ Receptor.