Emerging Therapeutic Strategies to Overcome Drug Resistance in Multiple Myeloma.

ABSTRACT: Multiple myeloma is a malignant plasma cell neoplasm that remains incurable and is ultimately fatal when patients acquire multi-drug resistance. Thus, advancing our understanding of the mechanisms behind drug resistance in multi-relapsed patients is critical for developing better strategies to extend their lifespan. Here, we review the understanding of resistance to the three key drug classes approved for multiple myeloma treatment: immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies. We consider how the complex, heterogenous biology of multiple myeloma may influence the acquisition of drug resistance and reflect on the gaps in knowledge where additional research is needed to improve our treatment approaches. Fortunately, many agents are currently being evaluated precl

SUBMITTER: Davis LN 

PROVIDER: S-EPMC8038312 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature