Immune Milieu Established by Postpartum Liver Involution Promotes Breast Cancer Liver Metastasis.

ABSTRACT: In rodents, we identified a physiologic process within the normal liver that creates a pre-metastatic niche. This physiology is weaning-induced liver involution, characterized by hepatocyte cell death, immune influx, and extracellular matrix remodeling. Here, using weaning-induced liver involution as a model of a physiologically regulated pro-metastatic niche, we investigate how liver involution supports breast cancer metastasis. Liver metastases were induced in BALB/c immune competent hosts by portal vein injection of D2OR (low metastatic) or D2A1 (high metastatic) mouse mammary tumor cells. Tumor incidence and multiplicity increased in involution hosts with no evidence of a proliferation advantage. D2OR tumor cell extravasation, seeding, and early survival were not enhanced in the involu

SUBMITTER: Bartlett AQ 

PROVIDER: S-EPMC8038410 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature