Kidney inflammaging is promoted by CCR2⁺ macrophages and tissue-derived micro-environmental factors.

ABSTRACT: The incidence of disorders associated with low inflammatory state, such as chronic kidney disease, increases in the elderly. The accumulation of senescent cells during aging and the senescence-associated secretory phenotype, which leads to inflammaging, is known to be deleterious and account for progressive organ dysfunction. To date, the cellular actors implicated in chronic inflammation in the kidney during aging are still not well characterized. Using the DECyt method, based on hierarchical clustering of flow cytometry data, we showed that aging was associated with significant changes in stromal cell diversity in the kidney. In particular, we identified two cell populations up-regulated with aging, the mesenchymal stromal cell subset (kMSC) expressing CD73 and the monocyte-derived Ly6C<

SUBMITTER: Lefevre L 

PROVIDER: S-EPMC8038964 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature