The association between depressive mood and ischemic heart disease: a twin study.

ABSTRACT:

Objective

Individuals with mood disorders have increased risk of cardiovascular disease. The aims of this study were to evaluate if the risk of cardiovascular disease in individuals with mood disorder could be explained by shared genetic and early environmental factors.

Methods

We included 6714 Danish middle and old aged twins from two large population-based studies. Cox proportional hazards regression was used to perform individual-level and intra-pair analyses of the association between self-reported depression symptomatology scores and register-based diagnoses of ischemic heart disease.

Results

Higher depression symptomatology scores (both total, affective, and somatic) were associated with higher incidence of ischemic heart disease after multivariable adjustment i

SUBMITTER: Wium-Andersen MK 

PROVIDER: S-EPMC8039049 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature