Characterization of AKT Somatic Mutations in Chinese Breast Cancer Patients.

ABSTRACT:

Purpose

This study aimed to investigate AKT gene mutation status in Chinese breast cancer patients.

Methods

The study included 411 breast cancer patients hospitalized in Guangdong Provincial People's Hospital (GDPH) from June 1, 2017 to September 27, 2018. Mastectomy or breast conserving surgery was performed, and tissue samples were subjected to next-generation sequencing (NGS) to determine AKT gene mutation status. Meanwhile, the expression of human epidermal growth factor receptor 2 (Her2), progesterone receptor (PR), and estrogen receptor (ER) was analyzed by immunohistochemistry staining. The Cancer Genome Atlas (TCGA) database was used for comparative studies.

Results

Patients in the GDPH cohort had an older age (P < 0.001), higher postmenopausal rate (

SUBMITTER: Wen L 

PROVIDER: S-EPMC8039050 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature