Decreased blood CD4+ T lymphocyte helps predict cognitive impairment in patients with amyotrophic lateral sclerosis.

ABSTRACT:

Background

ALS patients have changed peripheral immunity. It is unknown whether peripheral immunity is related to cognitive dysfunction in ALS patients.

Objective

To explore the relationship between the peripheral blood lymphocyte subsets and the cognitive status in ALS patients.

Methods

Among 81 ALS patients, we compared the demographic, clinical, and peripheral levels of total T lymphocyte, CD4+ T lymphocyte, CD8+ T lymphocyte, B lymphocyte, and NK cell between those with cognitive impairment (ALS-ci) and those without (ALS-nci). The cognitive status was evaluated via the Chinese version of the Edinburgh cognitive and behavioral screen (ECAS). Significant predictors of cognitive impairment in univariate logistic regression analysis were further examined using multiv

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8039093 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature