C. elegans detects toxicity of traumatic brain injury generated tau.

ABSTRACT: Traumatic brain injury (TBI) is associated with widespread tau pathology in about 30% of patients surviving late after injury. We previously found that TBI in mice induces the formation of an abnormal form of tau (tau^TBI) which progressively spreads from the site of injury to remote brain regions. Intracerebral inoculation of TBI brain homogenates into naïve mice induced progressive tau pathology, synaptic loss and late cognitive decline, suggesting a pivotal role of tau^TBI in post-TBI neurodegeneration. However, the possibility that tau^TBI was a marker of TBI-associated neurodegeneration rather than a toxic driver of functional decline could not be excluded. Here we employed the nematode C. elegans as a biosensor to test the pathogenic role of TBI generate

SUBMITTER: Zanier ER 

PROVIDER: S-EPMC8039186 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature