Association of Nuclear Factor Erythroid-2-Related Actor 2 Gene Polymorphisms with Diabetic Nephropathy in Chinese Patients.

ABSTRACT:

Aim

Nuclear factor erythroid-2-related factor 2 (NRF2) has emerged as a therapeutic target in many diseases. To explore this further, we evaluated the relationships between the -617C/A (rs6721961) polymorphisms within the NRF2 promoter and diabetic nephropathy (DN) in Chinese Han patients with type 2 diabetes mellitus (T2DM).

Methods

A total of 883 subjects with T2DM (500 without and 383 with DN) were enrolled in this study. Multivariable linear regression models were carried out to assess the association of DN with the -617C/A (rs6721961) polymorphisms.

Results

The AA genotype frequencies in patients with DN were significantly lower than those in patients without DN (χ² = 8.04, p = 0.018). Multivariate logistic regression analyses showed that indivi

SUBMITTER: Wang J 

PROVIDER: S-EPMC8039206 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature