Potential Genes and Mechanisms Linking Intracerebral Hemorrhage and Depression: A Bioinformatics-Based Study.

ABSTRACT:

Purpose

The purpose of this study was to investigate the potential pathogenic mechanisms of post-intracerebral hemorrhage depression.

Methods

Profiles of gene expression in brain tissue of patients with intracerebral hemorrhage (ICH) or depression were downloaded from the Gene Expression Omnibus (GEO) database. We analyzed differentially expressed genes (DEGs) for the two diseases separately. With these DEGs, we conducted an enrichment analysis based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) as well as cross-talk analysis, then we identified hub bridge genes using integrated bridge landscape analysis.

Results

We found 131 DEGs for interaction between ICH and depression. In the enrichment analysis, we found 55 GO terms and KEGG pathways i

SUBMITTER: Zou C 

PROVIDER: S-EPMC8039224 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature