Ontology highlight
ABSTRACT:
SUBMITTER: Zhao D
PROVIDER: S-EPMC8039390 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Zhao Dong D Xu Yi-Ming YM Cao Lu-Qi LQ Yu Feng F Zhou Huan H Qin Wei W Li Hui-Jin HJ He Chun-Xia CX Xing Lu L Zhou Xin X Li Peng-Quan PQ Jin Xin X He Yuan Y He Jian-Hua JH Cao Hui-Ling HL
Frontiers in cell and developmental biology 20210329
SNX-2112, as a promising anticancer lead compound targeting heat shock protein 90 (Hsp90), absence of complex crystal structure of Hsp90 <sup><i>N</i></sup> -SNX-2112 hindered further structural optimization and understanding on molecular interaction mechanism. Herein, a high-resolution complex crystal structure of Hsp90 <sup><i>N</i></sup> -SNX-2112 was successfully determined by X-ray diffraction, resolution limit, 2.14 Å, PDB ID 6LTK, and their molecular interaction was analyzed in detail, wh ...[more]