Modeling longitudinal changes in hippocampal subfields and relations with memory from early- to mid-childhood.

ABSTRACT: The hippocampus has been suggested to show protracted postnatal developmental growth across childhood. Most previous studies during this developmental period have been cross-sectional in nature and have focused on age-related differences in either hippocampal subregions or subfields, but not both, potentially missing localized changes. This study capitalized on a latent structural equation modeling approach to examine the longitudinal development of hippocampal subfields (cornu ammonis (CA) 2-4/dentate gyrus (DG), CA1, subiculum) in both the head and the body of the hippocampus, separately, in 165 typically developing 4- to 8-year-old children. Our findings document differential development of subfields within hippocampal head and body. Specifically, within hippocampal head, CA1 volume inc

SUBMITTER: Canada KL 

PROVIDER: S-EPMC8039550 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature