How do we counsel men with obstructive azoospermia due to CF mutations?-a review of treatment options and outcomes.

ABSTRACT: Obstructive azoospermia (OA) is a rare cause of male infertility, with Congenital Bilateral Absence of The Vas Deferens (CBAVD) being a major cause. A wealth of literature has established an irrefutable link between CFTR mutations and CBAVD, with CBAVD affecting almost all men with cystic fibrosis (CF) disease and a significant portion of men that are CFTR mutation carriers. In the past two decades, assisted reproductive technologies have made the prospect of fathering children a viable possibility in this subset of men, using a combination of sperm extraction techniques and intracystoplasmic sperm injection (ICSI). In order to assess techniques for sperm retrieval, as well as reproductive outcomes, a systemic search of the MEDLINE database was conducted for all articles pert

SUBMITTER: Persily JB 

PROVIDER: S-EPMC8039579 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature