The influence of lncRNAs on the prognosis of prostate cancer based on TCGA database.

ABSTRACT:

Background

Prostate adenocarcinoma (PRAD) is a common male urinary system cancer globally with a poor prognosis. Our research aims to explore the role of LncRNA in the occurrence and prognosis of prostate cancer and its underlying mechanism.

Methods

The biomaRt package screened for the differentially expressed lncRNA. The survival package was used to identify lncRNAs related to prognosis. The survminer package completed the Kaplan-Meier survival curves. WGCNA (Weighted Gene Co-Expression Network Analysis) screened for the co-expressed genes. The ClusterProfiler package implemented the analysis results of GO (gene ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes).

Results

We performed differential expression analysis on the TCGA (The Cancer Genome Atlas) dat

SUBMITTER: Huang H 

PROVIDER: S-EPMC8039585 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature