Relationship of frailty with treatment modality selection in patients with muscle-invasive bladder cancer (FRART-BC study).

ABSTRACT:

Background

We aimed to investigate the association of frailty with treatment selection in patients with muscle-invasive bladder cancer (MIBC) as frailty is one of the key factors for modality selection.

Methods

We retrospectively evaluated frailty in 169 patients with MIBC from January 2014 to September 2020 using the Fried phenotype, modified frailty index, and frailty discriminant score. The primary purpose was comparing the frailty between the patients who underwent radical cystectomy (RC) with those who had trimodal therapy (TMT) for bladder preservation. Secondary purposes were comparing the frailty between the groups and the effect of TMT on overall survival adjusting the frailty by multivariate Cox proportional hazards analysis using inverse probability of treatment w

SUBMITTER: Iwamura H 

PROVIDER: S-EPMC8039590 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature