Endoplasmic reticulum oxidoreductase 1 alpha modulates prostate cancer hallmarks.

ABSTRACT:

Background

Therapies available for late stage prostate cancer (PCa) patients are limited and mostly palliative. The necessary development of unexplored therapeutic options relies on a deeper knowledge of molecular mechanisms leading to cancer progression. Redox signals are known to modulate the intensity and duration of oncogenic circuits; cues originating from the endoplasmic reticulum (ER) and downstream exocytic organelles are relevant in secretory tumors, including PCa. Ero 1α is a master regulator of redox homeostasis and oxidative folding.

Methods

We assessed Ero 1α mRNA expression by bioinformatic analysis of three public datasets and protein expression levels in PCa cell lines representing different degrees of tumor progression and different human prostate specimens.

SUBMITTER: Cornelius J 

PROVIDER: S-EPMC8039598 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature