Defining new genetic etiologies of male infertility: progress and future prospects.

ABSTRACT: Male infertility is a common and complex disease, manifesting as a wide range of phenotypes, ranging from apparently normal semen parameters with an inexplicable inability to conceive, to the complete absence of sperm production. The diversity of male infertility phenotypes, coupled with the extreme complexity of spermatogenesis has significantly confounded the identification of the underlying genetic causes for these conditions, though incremental progress has been made, particularly in the past decade. In this review, we discuss the progress that has been made to date, tools and resources that have proven effective in accelerating discovery of novel genetic markers for male infertility, and areas in which we see the greatest potential for advancing the field in the coming years. These in

SUBMITTER: Salas-Huetos A 

PROVIDER: S-EPMC8039605 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature