Identification and validation of a five apoptosis-related genes signature for prediction of disease-free survival for testicular germ cell tumors.

ABSTRACT:

Background

More and more studies have paid attention to the role of apoptosis in tumorigenesis. A variety of apoptosis-related genes (ARGs) are related to tumor progression and resistance to chemotherapy drugs. Therefore, this study aims to establish a prognostic marker for ARG-based testicular germ cell tumors (TCGT).

Methods

TCGT sequencing data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) database and GEO database. The sequencing data of normal tissues came from the GTEx database. Through univariate COX, LASSO, and multiple COX regression analyses, we screened out key ARGs related to prognosis and constructed a risk signature and a prognostic nomogram. Finally, we performed internal and external verification to verify the signature we have

SUBMITTER: Zeng T 

PROVIDER: S-EPMC8039626 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature