Macrophage regulator of G-protein signaling 12 contributes to inflammatory pain hypersensitivity.

ABSTRACT:

Background

Pain is a predominant symptom in rheumatoid arthritis (RA) patients that results from joint inflammation and is augmented by central sensitization. Regulator of G-protein signaling 12 (RGS12) is the largest protein in the RGS protein family and plays a key role in the development of inflammation. This study investigated the regulation of RGS12 in inflammatory pain and explored the underlying mechanisms and potential RA pain targets.

Methods

Macrophage-specific RGS12-deficient (LysM-Cre⁺;RGS12^fl/fl) mice were generated by mating RGS12^fl/fl mice with LysM-Cre⁺ transgenic mice. Collagen antibody-induced arthritis (CAIA) models were induced in LysM-Cre⁺;RGS12^fl/fl mice by the administration of a cocktai

SUBMITTER: Yuan G 

PROVIDER: S-EPMC8039686 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature