New Modalities of 3D Pluripotent Stem Cell-Based Assays in Cardiovascular Toxicity.

ABSTRACT: The substantial progress of the human induced pluripotent stem cell (hiPSC) technologies over the last decade has provided us with new opportunities for cardiovascular drug discovery, regenerative medicine, and disease modeling. The combination of hiPSC with 3D culture techniques offers numerous advantages for generating and studying physiological and pathophysiological cardiac models. Cells grown in 3D can overcome many limitations of 2D cell cultures and animal models. Furthermore, it enables the investigation in an architecturally appropriate, complex cellular environment in vitro. Yet, generation and study of cardiac organoids-which may contain versatile cardiovascular cell types differentiated from hiPSC-remain a challenge. The large-scale and high-throughput applications requi

SUBMITTER: Orsolits B 

PROVIDER: S-EPMC8039822 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature