Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.

ABSTRACT: Background: Pathological angiogenesis is the hallmark of many vision-threatening diseases. Anti-VEGF is a primary treatment with substantial beneficial effects. However, such agents require frequent intravitreal injections. Our previous work established a method for effectively modifying exosomes (EXOs) for loading therapeutic peptides. Here, we used this system to load the anti-angiogenic peptide KV11, aiming to establish an EXO-based therapy strategy to suppress neovascularization in the retina. Methods: Using an anchoring peptide, CP05, we linked KV11 to endothelial cell (EC) derived EXOs, yielding EXO_KV11. We tested the delivery efficiency of EXO_KV11 via two commonly used ocular injection methods: retro-orbital injection and intravitreal injection. D

SUBMITTER: Dong X 

PROVIDER: S-EPMC8039955 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature