Detection of iron deficiency in children with Down syndrome.

ABSTRACT:

Purpose

Current American Academy of Pediatrics guidelines for children with Down syndrome (DS) recommend a complete blood count (CBC) at birth and hemoglobin annually to screen for iron deficiency (ID) and ID anemia (IDA) in low-risk children. We aimed to determine if macrocytosis masks the diagnosis of ID/IDA and to evaluate the utility of biochemical and red blood cell indices for detecting ID/IDA in DS.

Methods

We reviewed data from 856 individuals from five DS specialty clinics. Data included hemoglobin, mean corpuscular volume, red cell distribution width (RDW), percent transferrin saturation (TS), ferritin, and c-reactive protein. Receiver operating characteristic curves were calculated.

Results

Macrocytosis was found in 32% of the sample. If hemoglobin alone wa

SUBMITTER: Hart SJ 

PROVIDER: S-EPMC8039980 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature