Systematic optimization of the yeast cell factory for sustainable and high efficiency production of bioactive ginsenoside compound K.

ABSTRACT: Ginsenoside Compound K (CK) has been recognized as a major functional component that is absorbed into the systemic circulation after oral administration of ginseng. CK demonstrates diverse bioactivities. A phase I clinical study indicated that CK was a potential candidate for arthritis therapy. However, a phase II clinical study was suspended because of the high cost associated with the present CK manufacturing approach, which is based on the traditional planting-extracting-biotransforming process. We previously elucidated the complete CK biosynthetic pathway and realized for the first time de novo biosynthesis of CK from glucose by engineered yeast. However, CK production was not sufficient for industrial application. Here, we systematically engineered Saccharomyces cerevisiae</

SUBMITTER: Wang P 

PROVIDER: S-EPMC8040117 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature