Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates.

ABSTRACT:

Background

Clinical studies show that children exposed to anaesthetics for short times at young age perform normally on intelligence tests, but display altered social behaviours. In non-human primates (NHPs), infant anaesthesia exposure for several hours causes neurobehavioural impairments, including delayed motor reflex development and increased anxiety-related behaviours assessed by provoked response testing. However, the effects of anaesthesia on spontaneous social behaviours in juvenile NHPs have not been investigated. We hypothesised that multiple, but not single, 5 h isoflurane exposures in infant NHPs are associated with impairments in specific cognitive domains and altered social behaviours at juvenile age.

Methods

Eight Rhesus macaques per group were anaesthetised f

SUBMITTER: Neudecker V 

PROVIDER: S-EPMC8040121 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature