Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population.

ABSTRACT:

Objective

An unmet need exists for a non-invasive biomarker assay to aid gastric cancer diagnosis. We aimed to develop a serum microRNA (miRNA) panel for identifying patients with all stages of gastric cancer from a high-risk population.

Design

We conducted a three-phase, multicentre study comprising 5248 subjects from Singapore and Korea. Biomarker discovery and verification phases were done through comprehensive serum miRNA profiling and multivariant analysis of 578 miRNA candidates in retrospective cohorts of 682 subjects. A clinical assay was developed and validated in a prospective cohort of 4566 symptomatic subjects who underwent endoscopy. Assay performance was confirmed with histological diagnosis and compared with Helicobacter pylori (HP) serology, serum peps

SUBMITTER: So JBY 

PROVIDER: S-EPMC8040159 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature