Comparative genomics identifies thousands of candidate structured RNAs in human microbiomes.

ABSTRACT:

Background

Structured RNAs play varied bioregulatory roles within microbes. To date, hundreds of candidate structured RNAs have been predicted using informatic approaches that search for motif structures in genomic sequence data. The human microbiome contains thousands of species and strains of microbes. Yet, much of the metagenomic data from the human microbiome remains unmined for structured RNA motifs primarily due to computational limitations.

Results

We sought to apply a large-scale, comparative genomics approach to these organisms to identify candidate structured RNAs. With a carefully constructed, though computationally intensive automated analysis, we identify 3161 conserved candidate structured RNAs in intergenic regions, as well as 2022 additional candidate structu

SUBMITTER: Fremin BJ 

PROVIDER: S-EPMC8040213 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature