NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer.

ABSTRACT: Breast cancer is the most diagnosed malignancy in women. Increasing evidence has highlighted the importance of chronic inflammation at the local and/or systemic level in breast cancer pathobiology, influencing its progression, metastatic potential and therapeutic outcome by altering the tumor immune microenvironment. These processes are mediated by a variety of cytokines, chemokines and growth factors that exert their biological functions either locally or distantly. Inflammasomes are protein signaling complexes that form in response to damage- and pathogen-associated molecular patterns (DAMPS and PAMPS), triggering the release of pro-inflammatory cytokines. The dysregulation of inflammasome activation can lead to the development of inflammatory diseases, neurodegeneration, and cancer. A c

SUBMITTER: Faria SS 

PROVIDER: S-EPMC8040227 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature