Assessing breast cancer risk models in Marin County, a population with high rates of delayed childbirth.

ABSTRACT:

Introduction

This study was designed to compare the Breast Cancer Risk Assessment Tool (BCRAT; Gail), International Breast Intervention Study (IBIS; Tyrer-Cuzick), and BRCAPRO breast cancer risk assessment models using data from the Marin Women's Study, a cohort of women within Marin County, California, with high rates of breast cancer, nulliparity, and delayed childbirth. Existing models have not been well-validated in these high-risk populations.

Methods

Discrimination was assessed using the area under the receiver operating characteristic curve (AUC) and calibration by estimating the ratio of expected-to-observed (E/O) cases. The models were assessed using data from 12,843 participants, of whom 203 had developed cancer during a 5-year period. All tests of statistical sign

SUBMITTER: Powell M 

PROVIDER: S-EPMC8040293 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature