Lewy Body Disease is a Contributor to Logopenic Progressive Aphasia Phenotype.

ABSTRACT:

Objective

The objective of this study was to describe clinical features, [¹⁸ F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET) metabolism and digital pathology in patients with logopenic progressive aphasia (LPA) and pathologic diagnosis of diffuse Lewy body disease (DLBD) and compare to patients with LPA with other pathologies, as well as patients with classical features of probable dementia with Lewy bodies (pDLB).

Methods

This is a clinicopathologic case-control study of 45 patients, including 20 prospectively recruited patients with LPA among whom 6 were diagnosed with LPA-DLBD. We analyzed clinical features and compared FDG-PET metabolism in LPA-DLBD to an independent group of patients with clinical pDLB and regional α-synuclein burden on digital

SUBMITTER: Buciuc M 

PROVIDER: S-EPMC8040336 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature